Description

4-Chloro-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-amine is a high-value, fluorinated pyrazole derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both chloro and trifluoroethyl substituents, makes it an essential intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily targeted at research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorinated motifs for enhanced bioactivity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in areas like kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the trifluoroethyl group can improve lipophilicity and biological activity.
• Material Science Research: Serves as a precursor for novel fluorinated heterocyclic compounds with potential applications in organic electronics or specialty polymers.
• Chemical Biology Probes: Utilized in the design of molecular probes and tags for studying biological processes, leveraging its fluorine atoms for potential use in 19F NMR spectroscopy.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and contract research organizations (CROs) working on client-specific fluorinated targets.

Basic Information

Product Name	4-Chloro-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-amine
CAS No.	1006448-56-1
Molecular Formula	C5H5ClF3N3
Molecular Weight	199.56 g/mol
Synonyms	4-Chloro-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-amine; 3-Amino-4-chloro-1-(2,2,2-trifluoroethyl)pyrazole; 4-Chloro-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-ylamine; 1H-Pyrazol-3-amine, 4-chloro-1-(2,2,2-trifluoroethyl)-; 4-Chloro-1-(trifluoroethyl)-1H-pyrazol-3-amine
EINECS	Contact for details

Quality Control

Our 4-Chloro-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our commitment to quality supports your R&D and scale-up processes with reliable, high-purity material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.