Description

Methyl 3-[5-Cyclopropyl-3-(Trifluoromethyl)-1H-Pyrazol-1-Yl]-2-Methylpropanoate is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active ingredients. This compound is valued for its role as a key building block in modern medicinal chemistry, offering a versatile pyrazole core with a cyclopropyl and trifluoromethyl group for targeted molecular design. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in areas requiring specific bioisosteric replacements and metabolic stability.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Research: Serves as a key scaffold for developing new generation pesticides and herbicides, leveraging the biological activity of the pyrazole moiety.
• Chemical Biology & Proteomics: Used in the design and synthesis of chemical probes and activity-based probes (ABPs) for studying enzyme function and protein interactions.
• Material Science: Potential monomer or additive for creating specialty polymers with unique thermal or chemical resistance properties.
• Contract Research & Development (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client projects.

Basic Information

Product Name	Methyl 3-[5-Cyclopropyl-3-(Trifluoromethyl)-1H-Pyrazol-1-Yl]-2-Methylpropanoate
CAS No.	1005700-15-1
Molecular Formula	C13H17F3N2O2
Molecular Weight	290.28 g/mol
Synonyms	Methyl 2-methyl-3-[5-cyclopropyl-3-(trifluoromethyl)pyrazol-1-yl]propanoate; 1H-Pyrazole-1-propanoic acid, 5-cyclopropyl-3-(trifluoromethyl)-, methyl ester, α-methyl-; Propanoic acid, 3-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-methyl-, methyl ester; Methyl 3-(5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)-2-methylpropanoate
EINECS	Contact for details

Quality Control

Our production of Methyl 3-[5-Cyclopropyl-3-(Trifluoromethyl)-1H-Pyrazol-1-Yl]-2-Methylpropanoate adheres to stringent quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We operate under a quality system designed to meet the expectations of GMP for intermediates and support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider holding under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.