Description

1-Azoniabicyclo[2.2.2]Octane, 3-[[[(3-Fluorophenyl)[(3,4,5-Trifluorophenyl)Methyl]Amino]Carbonyl]Oxy]-1-[2-Oxo-2-(2-Thienyl)Ethyl]-, Bromide,(3R)- is a high-purity, advanced pharmaceutical intermediate featuring a complex, functionalized quinuclidinium core. This compound matters for its critical role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system (CNS) and other specialized therapeutic areas. Pharmaceutical R&D teams and fine chemical manufacturers need this precisely engineered building block to develop next-generation drugs with enhanced efficacy and selectivity.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of complex drug candidates, especially in medicinal chemistry programs.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for novel APIs, particularly those with neurological or psychiatric indications.
• Asymmetric Synthesis: Its (3R)- stereochemistry makes it valuable for constructing molecules with specific chiral centers required for biological activity.
• Chemical Biology & Probe Development: Employed in the creation of molecular probes for studying biological pathways and target validation.
• Process Chemistry & Scale-Up: Suitable for optimization and kilogram-scale production under current Good Manufacturing Practice (cGMP) conditions for clinical trial material supply.
• Contract Research & Manufacturing (CRAM): A critical material for organizations providing custom synthesis and development services to the biopharma industry.

Basic Information

Item	Details
Product Name	1-Azoniabicyclo[2.2.2]Octane, 3-[[[(3-Fluorophenyl)[(3,4,5-Trifluorophenyl)Methyl]Amino]Carbonyl]Oxy]-1-[2-Oxo-2-(2-Thienyl)Ethyl]-, Bromide,(3R)-
CAS No.	1004312-94-0
Molecular Formula	C27H24BrF4N2O3S
Molecular Weight	627.46 g/mol
Synonyms	(3R)-3-({[(3-Fluorophenyl)[(3,4,5-trifluorophenyl)methyl]carbamoyl]oxy})-1-[2-oxo-2-(thiophen-2-yl)ethyl]quinuclidinium bromide; (R)-3-((((3-Fluorophenyl)((3,4,5-trifluorophenyl)methyl)carbamoyl)oxy)-1-(2-oxo-2-(thiophen-2-yl)ethyl)quinuclidinium bromide; Quinuclidinium, 3-[[[[(3-fluorophenyl)[(3,4,5-trifluorophenyl)methyl]amino]carbonyl]oxy]-1-[2-oxo-2-(2-thienyl)ethyl]-, bromide, (3R)-; CAS 1004312-94-0; Advanced quinuclidine derivative intermediate; Fluorinated quinuclidinium salt.
EINECS	Contact for details

Quality Control

Our 1-Azoniabicyclo[2.2.2]Octane derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral assay, NMR for structural confirmation, and residual solvent analysis to ensure compliance with stringent specifications for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support development under quality agreements and can supply material suitable for use in cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in the original sealed container to prevent degradation. Allow the sealed container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.