Description

4-Bromo-1-(Phenylsulfonyl)-1H-Indazole is a high-purity, advanced pharmaceutical intermediate characterized by its distinct brominated indazole core with a phenylsulfonyl protecting group. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel small-molecule drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic targets.
• Kinase Inhibitor Development: A valuable scaffold for creating potent and selective kinase inhibitors due to the indazole moiety.
• Chemical Biology Probes: Employed in the development of chemical probes to study specific biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic Research: Utilized in university laboratories for exploratory organic synthesis and methodology development.

Basic Information

Product Name	4-Bromo-1-(Phenylsulfonyl)-1H-Indazole
CAS No.	1001415-32-2
Molecular Formula	C13H9BrN2O2S
Molecular Weight	337.19 g/mol
Synonyms	1H-Indazole, 4-bromo-1-(phenylsulfonyl)-; 4-Bromo-1-(benzenesulfonyl)-1H-indazole; 4-Bromo-1-(phenylsulfonyl)indazole; 4-Bromo-1H-indazole-1-sulfonic acid phenyl ester; 4-Bromo-1-(phenylsulfonyl)indazole; 4-Bromo-1-(phenylsulfonyl)-1H-indazole; 4-Bromo-1-(phenylsulfonyl)indazole; 4-Bromo-1-(phenylsulfonyl)-1H-indazole
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-(Phenylsulfonyl)-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with research-grade and pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive (store away from light) and should be handled under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.