Description

1-Bromo-3-(cyclopropylmethyl)thiobenzene is a specialized organosulfur building block featuring a bromine substituent and a cyclopropylmethylthio group on a benzene ring. This compound is valued for its unique reactivity profile, where the bromine atom serves as a handle for cross-coupling reactions while the thioether moiety can act as a directing group or be further functionalized. It is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders or possessing sulfur-containing pharmacophores.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides where the cyclopropyl and thioether groups contribute to biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of advanced polymers and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom is amenable to Suzuki, Stille, and other palladium-catalyzed couplings to create biaryl and other complex structures.
• Ligand and Catalyst Development: The sulfur atom can coordinate to metals, making it useful for designing novel ligands in catalytic systems.
• Chemical Biology Probes: Utilized in the creation of molecular probes to study enzyme mechanisms or protein interactions.

Basic Information

Product Name	1-Bromo-3-(cyclopropylmethyl)thiobenzene
CAS No.	1000576-47-5
Molecular Formula	C10H11BrS
Molecular Weight	243.16 g/mol
Synonyms	3-Bromophenyl cyclopropylmethyl sulfide; (3-Bromophenyl)(cyclopropylmethyl) sulfide; 1-Bromo-3-(cyclopropylmethylthio)benzene; 3-Bromo(cyclopropylmethylthio)benzene; Cyclopropylmethyl 3-bromophenyl sulfide; CAS 1000576-47-5
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-(cyclopropylmethyl)thiobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality commitment ensures the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.