Description

1-(Tetrahydropyranyl)-1H-Indazole-5-Carboxylicacid is a high-purity, advanced pharmaceutical intermediate featuring a unique indazole core protected by a tetrahydropyranyl (THP) group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new therapeutic agents, particularly in oncology and CNS drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degradation therapeutics.
• Kinase Inhibitor Synthesis: The indazole moiety is a privileged structure in the development of selective kinase inhibitors for cancer therapy.
• Chemical Biology Probes: Utilized in the creation of molecular probes to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	1-(Tetrahydropyranyl)-1H-Indazole-5-Carboxylicacid
CAS No.	1000576-28-2
Molecular Formula	C13H14N2O3
Molecular Weight	246.26 g/mol
Synonyms	1-(Tetrahydropyran-2-yl)-1H-indazole-5-carboxylic acid; 1H-Indazole-5-carboxylic acid, 1-(tetrahydro-2H-pyran-2-yl)-; 1-THP-indazole-5-carboxylic acid; 5-Carboxy-1-(tetrahydropyran-2-yl)-1H-indazole; THP-Indazole-5-COOH; 1-(Oxan-2-yl)-1H-indazole-5-carboxylic acid; 1000576-28-2
EINECS	Contact for details

Quality Control

Our 1-(Tetrahydropyranyl)-1H-Indazole-5-Carboxylicacid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.