Description

4-Carboxy-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole, 2-(4-Carboxy-1H-Indazol-1-Yl)Tetrahydro-2H-Pyran is a high-purity, advanced pharmaceutical intermediate with the CAS number 1000576-23-7. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), offering a versatile building block for medicinal chemistry research and development. It is primarily needed by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical producers focused on developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly in oncology and other therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new chemical entities.
• API Development: Serves as a precursor in the multi-step synthesis of target Active Pharmaceutical Ingredients (APIs).
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services.
• Chemical Biology Probes: Can be utilized in the development of chemical probes for target validation and biological pathway studies.
• Academic Research: Employed in university and institutional labs for novel heterocyclic chemistry and synthetic methodology development.

Basic Information

Product Name	4-Carboxy-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole, 2-(4-Carboxy-1H-Indazol-1-Yl)Tetrahydro-2H-Pyran
CAS No.	1000576-23-7
Molecular Formula	C14H14N2O4
Molecular Weight	274.27 g/mol
Synonyms	1-(Oxan-2-yl)-1H-indazole-4-carboxylic acid; 2-(4-Carboxy-1H-indazol-1-yl)oxane; 1-(Tetrahydro-2H-pyran-2-yl)-1H-indazole-4-carboxylic acid; 4-Carboxy-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole; THP-Protected Indazole-4-carboxylic Acid; 1H-Indazole-4-carboxylic acid, 1-(tetrahydro-2H-pyran-2-yl)-; 1000576-23-7
EINECS	Contact for details

Quality Control

Our 4-Carboxy-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP (current Good Manufacturing Practice) standards where applicable, and our quality protocols are designed to meet the stringent requirements of global pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be incompatible with strong acids and organic solvents; keep away from such materials. For long-term storage, consider storing under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.