Description

6-(Trifluoromethyl)-1H-Indazol-5-Amine is a high-purity, functionalized indazole derivative characterized by a reactive amine group and a stable trifluoromethyl substituent. This compound is a critical pharmaceutical intermediate and building block for medicinal chemistry research, enabling the synthesis of novel bioactive molecules. It is primarily utilized by R&D teams in the pharmaceutical, agrochemical, and advanced material sectors for developing new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and anticancer drug discovery.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing compound libraries via amide coupling, reductive amination, and other amine-reactive chemistries.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and pesticides, leveraging the biological activity of the indazole scaffold.
• Material Science: Potential precursor for the synthesis of advanced organic materials, such as ligands for catalysts or components for electronic materials.
• Bioconjugation & Probe Development: The primary amine group allows for labeling and conjugation, useful in creating biochemical probes for diagnostic applications.

Basic Information

Product Name	6-(Trifluoromethyl)-1H-Indazol-5-Amine
CAS No.	1000373-75-0
Molecular Formula	C8H6F3N3
Molecular Weight	201.15 g/mol
Synonyms	5-Amino-6-(trifluoromethyl)-1H-indazole; 6-(Trifluoromethyl)-1H-indazol-5-amine; 1H-Indazol-5-amine, 6-(trifluoromethyl)-; 5-Amino-6-trifluoromethylindazole; 6-Trifluoromethyl-1H-indazol-5-ylamine
EINECS	Contact for details

Quality Control

Our 6-(Trifluoromethyl)-1H-Indazol-5-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and MS. We provide full traceability and detailed Certificates of Analysis (COA) to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.