Description

1-Acetyl-7-Bromo-5-Nitroindole is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its molecular architecture, featuring bromo and nitro substituents on the indole core, makes it a versatile precursor for constructing complex pharmacophores and functional materials. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the development of novel active compounds and specialty chemicals.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those targeting kinase inhibition or acting as protease inhibitors.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its halogenated nitro-indole structure.
• Material Science: Acts as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-deficient nitro group.
• Chemical Biology: Employed in the design and synthesis of molecular probes and activity-based protein profiling (ABPP) reagents.
• Academic & Contract Research: A valuable reagent for methodological studies in cross-coupling reactions, nucleophilic aromatic substitution, and indole functionalization chemistry.
• Dye & Pigment Intermediate: Potential use in the synthesis of specialized indole-based dyes and colorants.

Basic Information

Product Name	1-Acetyl-7-Bromo-5-Nitroindole
CAS No.	1000343-23-6
Molecular Formula	C10H7BrN2O3
Molecular Weight	283.08 g/mol
Synonyms	7-Bromo-5-nitro-1H-indol-1-yl ethanone; 1-(7-Bromo-5-nitro-1H-indol-1-yl)ethanone; 1-Acetyl-7-bromo-5-nitro-1H-indole; 7-Bromo-5-nitroindole-1-acetic acid methyl ester derivative (common misnomer); ABNI; 7-Br-5-NO2-1-Acetylindole
EINECS	Contact for details

Quality Control

Our 1-Acetyl-7-Bromo-5-Nitroindole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.