Description

6-Bromo-4-Fluoro 1H-Indazole-3-Methycarboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound serves as a critical building block in modern medicinal chemistry, enabling the synthesis of novel, targeted therapeutic agents. It is primarily sought after by pharmaceutical R&D departments and fine chemical manufacturers engaged in developing new drug candidates, particularly in oncology and CNS disease areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex small-molecule drug candidates targeting various disease pathways.
• Kinase Inhibitor Development: Used in the research and production of potent and selective kinase inhibitors for cancer therapy.
• Bromine/Fluorine Synthon: The presence of both bromine and fluorine atoms makes it a valuable synthon for introducing halogenated motifs to modulate drug metabolism and binding affinity.
• Indazole-Based Scaffold Synthesis: Serves as a core structure for constructing diverse indazole-containing libraries for high-throughput screening in drug discovery.
• Agrochemical Research: Potential intermediate in the development of new active ingredients for crop protection products.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers and advanced organic materials.

Basic Information

Product Name	6-Bromo-4-Fluoro 1H-Indazole-3-Methycarboxylate
CAS No.	1000341-53-6
Molecular Formula	C9H6BrFN2O2
Molecular Weight	273.06 g/mol
Synonyms	6-Bromo-4-fluoro-1H-indazole-3-carboxylic acid methyl ester; Methyl 6-bromo-4-fluoro-1H-indazole-3-carboxylate; 1H-Indazole-3-carboxylic acid, 6-bromo-4-fluoro-, methyl ester; 6-Bromo-4-fluoro-indazole-3-carboxylic acid methyl ester; 1000341-53-6
EINECS	Contact for details

Quality Control

Our 6-Bromo-4-Fluoro 1H-Indazole-3-Methycarboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong acids, bases, and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.