Description

3-Chloro-6-(Trifluoromethyl) (1H)Indazole is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique indazole scaffold substituted with both chloro and trifluoromethyl groups, offering a versatile platform for creating novel molecular architectures with tailored properties. This compound is primarily sought after by R&D and process chemistry teams in the pharmaceutical and agrochemical industries for the development of new active ingredients, where its structural motifs are leveraged to modulate bioactivity, metabolic stability, and physicochemical parameters.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in kinase inhibitor programs and central nervous system (CNS) targeted therapies.
• Agrochemical Synthesis: Serves as a crucial building block for creating novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and biological activity.
• Material Science Research: Used in the synthesis of advanced organic materials, including ligands for catalysis and components for organic electronic devices.
• Chemical Biology Probe Development: Employed to create selective molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specialized fluorinated heterocycles.

Basic Information

Product Name	3-Chloro-6-(Trifluoromethyl) (1H)Indazole
CAS No.	1000341-24-1
Molecular Formula	C8H4ClF3N2
Molecular Weight	220.58 g/mol
Synonyms	3-Chloro-6-(trifluoromethyl)-1H-indazole; 1H-Indazole, 3-chloro-6-(trifluoromethyl)-; 6-(Trifluoromethyl)-3-chloro-1H-indazole; 3-Chloro-6-trifluoromethyl-1H-indazole; 3-Chloro-6-trifluoromethylindazole
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our advanced intermediates. Each batch of 3-Chloro-6-(Trifluoromethyl) (1H)Indazole is analyzed using validated methods (HPLC, GC, NMR) to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical data is provided with every shipment. Our quality system supports development under cGMP guidelines as required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.