Description

3-Amino-5-Chloro-6-Methyl-7-Azaindole is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its unique azaindole scaffold, functionalized with amino and chloro groups, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where it serves as a key precursor for kinase inhibitors and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used as a building block for creating novel herbicides, fungicides, and plant growth regulators.
• Material Science Research: Employed in the synthesis of organic semiconductors, ligands for metal-organic frameworks (MOFs), and advanced polymers.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for designing chemical probes and inhibitors to study enzyme function and cellular pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specialized heterocyclic chemistry.

Basic Information

Product Name	3-Amino-5-Chloro-6-Methyl-7-Azaindole
CAS No.	1000340-14-6
Molecular Formula	C8H8ClN3
Molecular Weight	181.62 g/mol
Synonyms	5-Chloro-6-methyl-1H-pyrrolo[2,3-b]pyridin-3-amine; 7-Azaindole, 3-amino-5-chloro-6-methyl-; 3-Amino-5-chloro-6-methyl-1H-pyrrolo[2,3-b]pyridine; 5-Chloro-6-methyl-3-amino-7-azaindole; 6-Methyl-5-chloro-3-amino-7-azaindole; AZD-1480 Intermediate; Kinase Inhibitor Intermediate
EINECS	Contact for details

Quality Control

Our 3-Amino-5-Chloro-6-Methyl-7-Azaindole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.