Description

Ethyl 2-Pyrrolidin-1-Yl-4-(Trifluoromethyl)-1,3-Thiazole-5-Carboxylate is a high-value, synthetically versatile heterocyclic building block. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the trifluoromethyl and thiazole motifs are critical for modulating biological activity and physicochemical properties. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced material sectors seeking to introduce these potent functional groups into their target molecules.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Research: Used in the development of novel pesticides, herbicides, and fungicides, where the thiazole ring and trifluoromethyl group can enhance efficacy and environmental stability.
• Chemical Biology Probe Synthesis: Employed as a building block for creating molecular probes to study biological pathways and protein functions.
• Material Science Research: Acts as a monomer or functional additive in the development of specialty polymers and advanced organic materials with tailored electronic or surface properties.
• Custom Synthesis & Contract Manufacturing: A key starting material for fine chemical suppliers and CDMOs (Contract Development and Manufacturing Organizations) offering bespoke synthesis services.

Basic Information

Product Name	Ethyl 2-Pyrrolidin-1-Yl-4-(Trifluoromethyl)-1,3-Thiazole-5-Carboxylate
CAS No.	1000339-79-6
Molecular Formula	C11H13F3N2O2S
Molecular Weight	294.29 g/mol
Synonyms	Ethyl 2-(1-pyrrolidinyl)-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate; 5-Carboxyethyl-2-pyrrolidin-1-yl-4-trifluoromethylthiazole; 1,3-Thiazole-5-carboxylic acid, 2-(1-pyrrolidinyl)-4-(trifluoromethyl)-, ethyl ester; Ethyl 2-(pyrrolidin-1-yl)-4-(trifluoromethyl)thiazole-5-carboxylate; 1000339-79-6; 2-Pyrrolidin-1-yl-4-trifluoromethyl-thiazole-5-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-Pyrrolidin-1-Yl-4-(Trifluoromethyl)-1,3-Thiazole-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.