Description

2-Piperidin-1-Yl-4-(Trifluoromethyl)-1,3-Thiazole-5-Carboxylic Acid is a high-value heterocyclic building block and advanced pharmaceutical intermediate. This compound matters for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research targeting a range of therapeutic areas. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, especially in kinase inhibitor programs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its piperidine and trifluoromethyl-thiazole motifs.
• Agrochemical Synthesis: Serves as a precursor in the development of novel pesticides and herbicides.
• Chemical Biology Probes: Utilized in the design and synthesis of tool compounds for target validation and biochemical pathway analysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production.
• Academic Research: Employed in university and institutional labs for exploratory organic synthesis and methodology development.

Basic Information

Product Name	2-Piperidin-1-Yl-4-(Trifluoromethyl)-1,3-Thiazole-5-Carboxylic Acid
CAS No.	1000339-77-4
Molecular Formula	C10H11F3N2O2S
Molecular Weight	280.27 g/mol
Synonyms	2-(Piperidin-1-yl)-4-(trifluoromethyl)-1,3-thiazole-5-carboxylic acid; 4-(Trifluoromethyl)-2-(1-piperidinyl)-5-thiazolecarboxylic acid; 2-(1-Piperidinyl)-4-(trifluoromethyl)-5-thiazolecarboxylic acid; 5-Thiazolecarboxylic acid, 2-(1-piperidinyl)-4-(trifluoromethyl)-; CAS 1000339-77-4
EINECS	Contact for details

Quality Control

Our 2-Piperidin-1-Yl-4-(Trifluoromethyl)-1,3-Thiazole-5-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR/LC-MS for identity confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.