Description

4,6-Difluoro-2,3-Dihydro-1H-Indole Hydrochloride is a high-purity, fluorinated indole derivative salt, serving as a critical advanced pharmaceutical intermediate. Its value lies in its role as a versatile building block for synthesizing complex molecules with enhanced biological activity and metabolic stability. This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs), particularly in therapeutic areas like oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, especially those targeting protein kinases and other enzymes.
• Agrochemical Synthesis: Used in the creation of advanced, fluorinated active ingredients for crop protection products, leveraging fluorine's ability to improve lipophilicity and stability.
• Material Science Research: Acts as a precursor for organic electronic materials and specialty polymers where the indole scaffold and fluorine atoms impart specific electronic properties.
• Chemical Biology & Proteomics: Employed as a molecular probe or a tag in the study of biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Item	Detail
Product Name	4,6-Difluoro-2,3-Dihydro-1H-Indole Hydrochloride
CAS No.	199526-98-2
Molecular Formula	C8H8ClF2N
Molecular Weight	191.60 g/mol
Synonyms	4,6-Difluoro-2,3-dihydro-1H-indole HCl; 4,6-Difluoroindoline Hydrochloride; 1H-Indole, 4,6-difluoro-2,3-dihydro-, hydrochloride; 4,6-Difluoro-2,3-dihydroindole Hydrochloride; 4,6-Difluoroindoline HCl; 199526-98-2 (CAS); 4,6-Difluoro-1H-indole, 2,3-dihydro-, hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 4,6-Difluoro-2,3-Dihydro-1H-Indole Hydrochloride is manufactured under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.