Description

2,5-Diaza-Bicyclo[2.2.1]Heptane-2-Carboxylic Acid tert-Butyl Ester is a high-value, protected bicyclic diamino acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its rigid, constrained structure and orthogonal protecting groups make it indispensable for constructing complex molecular architectures with precise stereochemical control. This compound is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for the development of novel active pharmaceutical ingredients (APIs), peptidomimetics, and specialized ligands.

Application

• Pharmaceutical Intermediate: A key chiral scaffold in the synthesis of protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Peptidomimetic Chemistry: Used to introduce conformational rigidity into peptide backbones, enhancing metabolic stability and receptor selectivity.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands and organocatalysts used in enantioselective transformations.
• Chemical Biology & Proteomics: Employed in the design of activity-based probes and molecular tools for studying enzyme function.
• Agrochemical Research: Utilized in the discovery of new herbicides and fungicides with novel modes of action.
• Academic & Process Research: A valuable reagent for methodological development in organic synthesis and scale-up process optimization.

Basic Information

Product Name	2,5-Diaza-Bicyclo[2.2.1]Heptane-2-Carboxylic Acid tert-Butyl Ester
CAS No.	198989-07-0
Molecular Formula	C11H20N2O2
Molecular Weight	212.29 g/mol
Synonyms	(1R,4S)-2-(tert-Butoxycarbonyl)-2,5-diazabicyclo[2.2.1]heptane; tert-Butyl (1R,4S)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate; (1S,4R)-2-(tert-Butoxycarbonyl)-2,5-diazabicyclo[2.2.1]heptane; Boc-2,5-Diazabicyclo[2.2.1]heptane; Boc-DAB Heptane Ester; 2,5-DABCO Heptane Boc Ester; 2-(tert-Butoxycarbonyl)-2,5-diazabicyclo[2.2.1]heptane
EINECS	Contact for details

Quality Control

Our 2,5-Diaza-Bicyclo[2.2.1]Heptane-2-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening the container for extended periods to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.