Description

5(1H)-Indolizinone,2,3,6,8A-Tetrahydro-,(8As)-(9Ci) is a high-purity, advanced pharmaceutical intermediate belonging to the indolizinone class of heterocyclic compounds. This compound is of significant value for its role as a key synthetic building block in the research and development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new therapeutic agents and specialty molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Organic Synthesis Building Block: Used in research laboratories for constructing complex indolizine and related fused heterocyclic scaffolds, enabling exploration of new chemical space.
• Agrochemical Research: Employed in the development of new pesticides and herbicides, where the indolizinone core can contribute to novel modes of action.
• Material Science Precursor: Investigated for the synthesis of organic semiconductors and functional materials due to its conjugated system potential.
• Academic & Contract Research: Essential for universities and CROs (Contract Research Organizations) conducting fundamental research in heterocyclic and medicinal chemistry.

Basic Information

Product Name	5(1H)-Indolizinone,2,3,6,8A-Tetrahydro-,(8As)-(9Ci)
CAS No.	198218-82-5
Molecular Formula	C8H9NO
Molecular Weight	135.16 g/mol
Synonyms	(8aS)-2,3,6,8a-Tetrahydro-5(1H)-indolizinone; (8aS)-Octahydro-5H-indolizin-5-one; 2,3,6,8a-Tetrahydro-5H-indolizin-5-one, (8aS)-; 5H-Indolizin-5-one, 2,3,6,8a-tetrahydro-, (8aS)-; (8aS)-2,3,6,8a-Tetrahydroindolizin-5(1H)-one
EINECS	Contact for details

Quality Control

Our production of 5(1H)-Indolizinone,2,3,6,8A-Tetrahydro-,(8As)-(9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive R&D and scale-up processes. Each lot is fully characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.