Description

8-Azabicyclo[3.2.1]Octan-2-One,3-Fluoro-8-Methyl-,(1R,3S,5S)-Rel-(9Ci) is a high-purity, stereochemically defined pharmaceutical intermediate of significant commercial interest. This compound is valued for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in advanced drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel tropane alkaloid derivatives and other complex bioactive molecules.
• Drug Discovery & Development: Used in medicinal chemistry research for constructing molecular scaffolds with potential neurological activity.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a precursor in the multi-step manufacturing of specific APIs, leveraging its defined (1R,3S,5S) stereochemistry.
• Chemical Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Asymmetric Synthesis: Utilized in advanced organic synthesis to introduce a fluorinated, bridged bicyclic amine moiety into target compounds.

Basic Information

Product Name	8-Azabicyclo[3.2.1]Octan-2-One,3-Fluoro-8-Methyl-,(1R,3S,5S)-Rel-(9Ci)
CAS No.	198208-50-3
Molecular Formula	C8H12FNO
Molecular Weight	157.19 g/mol
Synonyms	(1R,3S,5S)-3-Fluoro-8-methyl-8-azabicyclo[3.2.1]octan-2-one; rel-(1R,3S,5S)-3-Fluoro-8-methyl-8-azabicyclo[3.2.1]octan-2-one; 3-Fluoro-8-methyl-8-azabicyclo[3.2.1]octan-2-one (rel-(1R,3S,5S)-form); 8-Azabicyclo[3.2.1]octan-2-one, 3-fluoro-8-methyl-, (1R,3S,5S)-rel-; 3-Fluoro-8-methyl-8-azabicyclo[3.2.1]octan-2-one (racemic endo-isomer reference); Fluorinated Tropinone Derivative
EINECS	Contact for details

Quality Control

Our 8-Azabicyclo[3.2.1]Octan-2-One,3-Fluoro-8-Methyl-,(1R,3S,5S)-Rel-(9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; handle and store under an inert atmosphere (e.g., nitrogen) for long-term stability, especially after opening the primary container.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (for specified enantiomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.