Description

2-Iodo-4-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Benzenemethanol is a highly specialized photoaffinity labeling reagent, a critical tool for probing biomolecular interactions and active sites. Its core value lies in the unique combination of a reactive diazirine group for covalent crosslinking upon photolysis and an iodo-substituted aromatic ring for further functionalization or detection. This compound is essential for researchers and developers in pharmaceutical discovery, chemical biology, and proteomics who require precise molecular mapping and target identification.

Application

• Photoaffinity Labeling (PAL): Primary application for irreversible covalent tagging of proteins, nucleic acids, or other biomolecules to study binding sites and interaction networks.
• Chemical Probe Development: Synthesis of activity-based probes (ABPs) for target identification and validation in drug discovery pipelines.
• Proteomics Research: Used in mass spectrometry-based studies to identify and characterize low-abundance protein targets and transient complexes.
• Bioconjugation & Linker Chemistry: The benzylic alcohol and iodoaryl groups serve as handles for conjugation to other molecules, surfaces, or reporter tags like fluorophores or biotin.
• Material Science Functionalization: Potential use in creating functionalized surfaces or polymers with specific photoreactive properties.
• Mechanistic Studies in Medicinal Chemistry: Elucidating the mode of action of drug candidates by identifying their direct molecular targets within cells.

Basic Information

Product Name	2-Iodo-4-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Benzenemethanol
CAS No.	197968-46-0
Molecular Formula	C9H6F3IN2O
Molecular Weight	354.06 g/mol
Synonyms	3-(3-(Hydroxymethyl)-4-iodophenyl)-3-(trifluoromethyl)diazirine; 4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)-2-iodobenzyl alcohol; 2-Iodo-4-(3-(trifluoromethyl)diazirin-3-yl)benzyl alcohol; 3-(4-Iodo-3-(hydroxymethyl)phenyl)-3-(trifluoromethyl)diazirine; Photoaffinity Labeling Reagent 197968-46-0; Benzyl alcohol, 2-iodo-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]-; TFD-Iodo-Benzyl Alcohol
EINECS	Contact for details

Quality Control

Every batch of 2-Iodo-4-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Benzenemethanol is manufactured and analyzed under strict quality protocols to ensure consistency and reliability for sensitive research applications. We employ advanced analytical techniques including HPLC, NMR, and MS to verify identity, purity, and functional integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed under inert atmosphere if specified and opened in a controlled, dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.