Description

Phosphoramidous Acid. N.n-Bis(1-Methylethyl)-. Bis(9H-Fluoren-9-Ylmethyl) Ester is a specialized organophosphorus compound featuring fluorenylmethyl protecting groups. This compound matters as a high-value, reactive intermediate crucial for the controlled synthesis of complex phosphorus-containing molecules, particularly in advanced research and development. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers working on novel nucleotide analogs, phosphoramidite precursors for oligonucleotide synthesis, and sophisticated ligand systems for catalysis.

Application

• Phosphoramidite Precursor: A key building block in the synthesis of advanced phosphoramidites for solid-phase oligonucleotide (DNA/RNA) synthesis.
• Pharmaceutical Intermediate: Used in the research and development of prodrugs and active pharmaceutical ingredients (APIs) containing phosphorus centers.
• Ligand Synthesis: Serves as a starting material for creating specialized phosphine and phosphinite ligands used in homogeneous catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of novel phosphorus-based polymers, flame retardants, or functional materials.
• Agrochemical Intermediate: Potential use in the synthesis of experimental herbicides, insecticides, or plant growth regulators.
• Process Development: Used by process chemists to optimize scalable routes to phosphorus-containing target molecules.

Basic Information

Product Name	Phosphoramidous Acid. N.n-Bis(1-Methylethyl)-. Bis(9H-Fluoren-9-Ylmethyl) Ester
CAS No.	197709-11-8
Molecular Formula	C37H40NO2P
Molecular Weight	561.69 g/mol
Synonyms	Bis(9H-fluoren-9-ylmethyl) diisopropylphosphoramidite; Diisopropylamino-bis(9-fluorenylmethoxy)phosphine; Fmoc-protected diisopropylphosphoramidite; N,N-Diisopropyl-bis(9-fluorenylmethyl) phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, bis(9H-fluoren-9-ylmethyl) ester; P(N(i-Pr)2)(OCH2Fm)2; Fluorenylmethyl-protected phosphoramidite
EINECS	Contact for details

Quality Control

Every batch of Phosphoramidous Acid. N.n-Bis(1-Methylethyl)-. Bis(9H-Fluoren-9-Ylmethyl) Ester is produced and tested under strict quality management systems. We ensure high purity and lot-to-lot consistency through comprehensive analytical techniques including NMR (1H, 13C, 31P) and HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and conformity to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a dedicated freezer. This material is easily oxidized and moisture-sensitive; ensure containers are sealed immediately after use and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
31P NMR Purity	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.