Description

2-Bromothiophene-3-Carbonyl Chloride is a high-purity, reactive organobromine building block essential for advanced organic synthesis. Its value lies in its dual functionality, serving as a versatile electrophile for introducing the 2-bromothiophene moiety while the acid chloride group enables facile amide and ester formation. This compound is critically needed by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of thiophene-based drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides that incorporate the bioactive thiophene heterocycle.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the production of conductive polymers and specialty organic electronic materials.
• Ligand and Catalyst Development: Foundation for synthesizing complex chelating ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Custom Chemical Synthesis: Employed in contract research and manufacturing (CRO/CMO) for producing bespoke compounds and labeled analogs for research.

Basic Information

Product Name	2-Bromothiophene-3-Carbonyl Chloride
CAS No.	197370-13-1
Molecular Formula	C5H2BrClOS
Molecular Weight	225.49 g/mol
Synonyms	3-Bromothiophene-2-carbonyl chloride; 2-Bromo-3-thiophenecarbonyl chloride; 2-Bromothiophene-3-carboxylic acid chloride; 3-Bromo-2-thiophenecarbonyl chloride; Thiophene-3-carbonyl chloride, 2-bromo-; 2-Bromo-thiophene-3-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our 2-Bromothiophene-3-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with full traceability are provided for every shipment, supporting compliance with cGMP and ISO 9001 standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.