Description

4-Chloro-3-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Benzoic Acid is a high-purity, functionalized benzoic acid derivative featuring a maleimide moiety, making it a versatile and valuable chemical building block for advanced synthesis. This compound is specifically engineered for applications requiring precise molecular conjugation and linkage, offering reliable performance in demanding research and production environments. It is primarily sought after by pharmaceutical researchers and specialty chemical manufacturers for the development of targeted drug conjugates, polymer modifiers, and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics via its reactive maleimide group.
• Bioconjugation Reagent: Used to covalently link drugs, probes, or polymers to biomolecules like proteins, peptides, and antibodies through thiol-maleimide chemistry.
• Polymer Science: Serves as a functional monomer or cross-linking agent for creating specialty polymers with tailored properties, such as hydrogels or responsive materials.
• Material Science: Employed in the surface functionalization of nanoparticles and other nanomaterials to impart specific chemical reactivity or biocompatibility.
• Research & Development: A critical tool in chemical biology and medicinal chemistry for probe development and studying biomolecular interactions.
• Diagnostic Reagents: Can be used in the development of diagnostic assays and imaging agents that require stable covalent attachments.

Basic Information

Item	Details
Product Name	4-Chloro-3-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Benzoic Acid
CAS No.	196865-76-6
Molecular Formula	C11H6ClNO4
Molecular Weight	251.62 g/mol
Synonyms	4-Chloro-3-maleimidobenzoic Acid; 3-Maleimido-4-chlorobenzoic Acid; 1-(4-Chloro-3-carboxyphenyl)-1H-pyrrole-2,5-dione; 4-Chloro-3-(maleimido)benzoic Acid; 4-Chloro-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid; 196865-76-6; 4-Chloro-3-maleimidobenzoic acid; Benzoic acid, 4-chloro-3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-
EINECS	Contact for details

Quality Control

Our production of 4-Chloro-3-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Benzoic Acid adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets precise customer specifications. Certificates of Analysis (COA) detailing all test results are provided with each shipment. We support development and cGMP-grade production for pharmaceutical applications, ensuring traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.