Description

Cyclohexanethiol,5-Methyl-2-(1-Methylethyl)-,(2S,5R)-[Partial]-(9Ci) is a high-purity, chiral thiol derivative of menthol, serving as a sophisticated sulfur-containing building block in advanced organic synthesis. Its value lies in the precise stereochemistry and the reactive thiol functional group, which enables the introduction of sulfur atoms into complex molecular architectures with high enantiomeric control. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, chiral ligands, and functional materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of sulfur-containing drug candidates, particularly in antiviral, anticancer, and central nervous system (CNS) targeted therapies.
• Agrochemical Synthesis: Used in the development of novel pesticides, herbicides, and fungicides where the chiral thiol moiety contributes to biological activity and selectivity.
• Chiral Ligand & Catalyst Preparation: Serves as a precursor for synthesizing chiral thiol-based ligands for asymmetric catalysis and metal complexation.
• Flavor & Fragrance Chemistry: Potential intermediate for creating sulfur-containing aroma compounds with unique sensory profiles, leveraging its menthol-related structure.
• Material Science Research: Employed in the synthesis of functionalized polymers, self-assembled monolayers (SAMs), and other advanced materials requiring precise surface modification.
• Chemical Biology Probes: Useful for bioconjugation and labeling applications due to the high reactivity of the thiol group towards maleimides and other electrophiles.

Basic Information

Product Name	Cyclohexanethiol,5-Methyl-2-(1-Methylethyl)-,(2S,5R)-[Partial]-(9Ci)
CAS No.	196622-67-0
Molecular Formula	C10H20S
Molecular Weight	172.33 g/mol
Synonyms	(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanethiol; (-)-Menthyl Mercaptan; (1R,2S,5R)-Menththiol; L-Menthyl Mercaptan; (1R,2S,5R)-2-(1-Methylethyl)-5-methylcyclohexanethiol; (1R,2S,5R)-Thiomenthol; (2S,5R)-5-Methyl-2-(propan-2-yl)cyclohexane-1-thiol
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Certificates of Analysis (COA) are provided with each shipment, detailing critical parameters such as chiral purity (by chiral GC or HPLC), chemical assay, and impurity profiles. We support development and commercial projects with GMP-compatible documentation and can tailor specifications to meet specific regulatory filing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, separate from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Chiral Purity (Chiral GC/HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.