Description

Methyl Octahydro-1H-Indole-2-Carboxylate Hydrochloride is a high-purity, pharmaceutically relevant intermediate characterized by its indole-based bicyclic structure. This compound matters as a critical building block in the synthesis of complex molecules, offering a versatile chiral scaffold for medicinal chemistry research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for creating novel active pharmaceutical ingredients (APIs) and exploring new therapeutic pathways.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of potential drug candidates, particularly those targeting the central nervous system.
• Medicinal Chemistry Research: Used as a constrained proline analog or a versatile scaffold for constructing compound libraries in hit-to-lead and lead optimization programs.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the production of advanced intermediates under Good Manufacturing Practice (GMP) conditions.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric transformations due to its embedded stereogenic centers.
• Chemical Biology Probes: Acts as a core structure for developing enzyme inhibitors or receptor modulators used in mechanistic studies.
• Reference Standard: Provides a high-purity material for analytical method development, validation, and quality control in API manufacturing.

Basic Information

Product Name	Methyl Octahydro-1H-Indole-2-Carboxylate Hydrochloride
CAS No.	195878-03-6
Molecular Formula	C10H18ClNO2
Molecular Weight	219.71 g/mol
Synonyms	Methyl 2-Octahydro-1H-indolecarboxylate Hydrochloride; Methyl cis-Octahydro-1H-indole-2-carboxylate Hydrochloride; 1H-Indole-2-carboxylic acid, octahydro-, methyl ester, hydrochloride; Methyl (2S,3aR,7aS)-Octahydro-1H-indole-2-carboxylate Hydrochloride (stereoisomer); Methyl Perhydroindole-2-carboxylate HCl; 2-Carbomethoxyoctahydroindole Hydrochloride; (2S,3aR,7aS)-2-(Methoxycarbonyl)octahydro-1H-indole Hydrochloride
EINECS	Contact for details

Quality Control

Our Methyl Octahydro-1H-Indole-2-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identification by IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.