Description

Diethyl (Fmoc-Aminomethyl)Phosphonate is a specialized organophosphorus building block of significant importance in modern synthetic chemistry. This compound is valued for its role as a key reagent in the synthesis of phosphonopeptides and other bioactive molecules, enabling the introduction of stable phosphonate isosteres. It is primarily sought after by research institutions and pharmaceutical companies engaged in drug discovery, medicinal chemistry, and the development of enzyme inhibitors.

Application

• Peptide Mimetics Synthesis: A crucial reagent for the solid-phase and solution-phase synthesis of Fmoc-protected phosphonopeptides, which serve as non-hydrolyzable phosphate mimics.
• Medicinal Chemistry & Drug Discovery: Used in constructing potential enzyme inhibitors, particularly targeting proteases, phosphatases, and kinases for therapeutic agent development.
• Chemical Biology Probes: Enables the creation of bioconjugates and activity-based probes to study phosphonate-dependent biological processes.
• Organocatalyst & Ligand Precursor: Serves as a starting material for synthesizing novel phosphonate-based ligands and catalysts for asymmetric synthesis.
• Material Science Intermediates: Used in the preparation of functionalized surfaces and polymers with specific chelating or bioactive properties.

Basic Information

Product Name	Diethyl (Fmoc-Aminomethyl)Phosphonate
CAS No.	195306-55-9
Molecular Formula	C₂₁H₂₆NO₅P
Molecular Weight	403.41 g/mol
Synonyms	Diethyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]aminomethylphosphonate; Diethyl [[(9-Fluorenylmethoxycarbonyl)amino]methyl]phosphonate; Fmoc-NH-CH2-P(O)(OEt)2; (Fmoc-Aminomethyl)phosphonic Acid Diethyl Ester; N-Fmoc-aminomethanephosphonic Acid Diethyl Ester; Diethyl (N-Fmoc-aminomethyl)phosphonate; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]aminomethylphosphonic Acid Diethyl Ester
EINECS	Contact for details

Quality Control

Our Diethyl (Fmoc-Aminomethyl)Phosphonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 1.0 %
Solubility	Soluble in DMF, DMSO, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.