Description

(1R)-5-Bromo-1-Methyl-2-Trityl-2,3-Dihydro-1H-Isoindole CAS NO 194805-14-6 is a high-purity, chiral isoindoline derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its value lies in its role as a key building block for constructing complex molecules with defined stereochemistry, enabling the development of novel active pharmaceutical ingredients (APIs) and specialty chemicals. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides where specific stereochemistry is required for biological activity.
• Ligand and Catalyst Synthesis: Serves as a precursor for creating chiral ligands used in asymmetric catalysis and transition metal complexes.
• Material Science: A potential monomer or intermediate for synthesizing specialty polymers and organic electronic materials.
• Academic & Contract Research: A valuable reagent for methodological development in organic synthesis and stereochemistry studies at research institutions and CROs.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial production.

Basic Information

Product Name	(1R)-5-Bromo-1-Methyl-2-Trityl-2,3-Dihydro-1H-Isoindole
CAS No.	194805-14-6
Molecular Formula	C28H24BrN
Molecular Weight	446.40 g/mol
Synonyms	(R)-5-Bromo-1-methyl-2-trityl-2,3-dihydro-1H-isoindole; (1R)-5-Bromo-1-methyl-2-triphenylmethyl-2,3-dihydro-1H-isoindole; 5-Bromo-1-methyl-2-trityl-(1R)-2,3-dihydro-1H-isoindole; (R)-5-Bromo-1-methyl-2-tritylisoindoline; 194805-14-6; (1R)-5-Bromo-1-methyl-2-trityl-isoindoline; (R)-1-Methyl-5-bromo-2-trityl-2,3-dihydro-1H-isoindole
EINECS	Contact for details

Quality Control

Our (1R)-5-Bromo-1-Methyl-2-Trityl-2,3-Dihydro-1H-Isoindole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Production adheres to cGMP guidelines where applicable, and all materials are supported by comprehensive analytical data. Certificates of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles are provided with each shipment to meet the stringent requirements of pharmaceutical and advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This material is light-sensitive and easily oxidized; prolonged exposure to air or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.