Description

L-Kynurenine-D4 Trifluoroacetic Acid Salt is a stable isotope-labeled internal standard essential for precise quantitative analysis in mass spectrometry. This high-purity compound is critical for ensuring accuracy and reliability in research and diagnostic applications where the quantification of the endogenous metabolite kynurenine is required. It is primarily utilized by analytical laboratories and pharmaceutical researchers in the fields of metabolomics, neuroscience, and drug development.

Application

• Quantitative Mass Spectrometry: Serves as a critical internal standard for the accurate LC-MS/MS quantification of endogenous L-Kynurenine in biological matrices such as plasma, serum, and cerebrospinal fluid.
• Biomarker Research: Enables precise measurement of kynurenine pathway metabolites in studies related to neurological disorders, immune function, and cancer.
• Drug Metabolism & Pharmacokinetics (DMPK): Used in stable isotope dilution assays to study the pharmacokinetics of drugs affecting the tryptophan-kynurenine pathway.
• Clinical Diagnostics: Supports the development and validation of clinical diagnostic assays for conditions linked to dysregulated tryptophan metabolism.
• Metabolomics & Proteomics: A key reagent in high-throughput profiling studies aiming to understand metabolic changes in disease states.
• Quality Control Reference: Acts as a certified reference material for calibrating analytical methods and ensuring data integrity in GLP/GMP environments.

Basic Information

Product Name	L-Kynurenine-D4 Trifluoroacetic Acid Salt
CAS No.	194546-33-3
Molecular Formula	C10H8D4N2O3 • C2HF3O2
Molecular Weight	Contact for details
Synonyms	L-Kynurenine-2,4,5,6-d4 TFA Salt; (S)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic-2,4,5,6-d4 Acid Trifluoroacetate; Kynurenine-d4; Deuterated L-Kynurenine TFA Salt; KYN-d4; 3-(2-Aminophenyl)-2-amino-3-hydroxypropanoic-2,4,5,6-d4 Acid Trifluoroacetic Acid Salt; Stable Isotope-Labeled Kynurenine Internal Standard
EINECS	Contact for details

Quality Control

Our L-Kynurenine-D4 Trifluoroacetic Acid Salt is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (chemical and isotopic purity >98%), HPLC purity, and absence of interfering impurities. We adhere to relevant industry standards for reference materials to guarantee reliable and reproducible performance in your assays.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium enrichment)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.