Description

3-(5-Bromo-2-Thienyl)-3-[(2,2,2-Trifluoroacetyl)Amino]Propanoic Acid is a high-purity, advanced pharmaceutical intermediate designed for complex synthesis pathways. This compound is valued for its unique molecular architecture, which incorporates both a bromothiophene moiety and a trifluoroacetyl-protected amino acid group, making it a critical building block for targeted drug discovery. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in areas requiring sophisticated heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Protease Inhibitor Research: Serves as a core scaffold for developing inhibitors of specific enzymes, leveraging its amino acid-like structure.
• Agrochemical Development: Used in research for creating new generation herbicides and pesticides, where the bromothiophene unit is significant for bioactivity.
• Material Science: Acts as a monomer or functionalizing agent in the synthesis of specialized polymers and organic electronic materials.
• Chemical Biology: Employed in the design and synthesis of activity-based probes (ABPs) and other tools for studying biological processes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific, multi-step synthetic projects.

Basic Information

Product Name	3-(5-Bromo-2-Thienyl)-3-[(2,2,2-Trifluoroacetyl)Amino]Propanoic Acid
CAS No.	194229-21-5
Molecular Formula	C9H7BrF3NO3S
Molecular Weight	346.12 g/mol
Synonyms	3-[(2,2,2-Trifluoroacetyl)amino]-3-(5-bromo-2-thienyl)propanoic acid; 3-Amino-3-(5-bromo-2-thienyl)propanoic acid N-trifluoroacetyl; 3-(5-Bromothiophen-2-yl)-3-[(2,2,2-trifluoroacetyl)amino]propanoic acid; N-Trifluoroacetyl-3-(5-bromo-2-thienyl)-3-aminopropanoic acid; 194229-21-5; 3-(5-Bromo-2-thienyl)-3-[(trifluoroacetyl)amino]propionic acid
EINECS	Contact for details

Quality Control

Every batch of 3-(5-Bromo-2-Thienyl)-3-[(2,2,2-Trifluoroacetyl)Amino]Propanoic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent batch-to-batch reliability, meeting the stringent requirements of pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.