Description

Fumaric Acid-D4 CAS NO 194160-45-7 is a deuterium-labeled isotopologue of fumaric acid, where four hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is essential for advanced analytical and research applications where precise molecular tracking is required. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry sectors for use as an internal standard in mass spectrometry, metabolic pathway studies, and drug development.

Application

• Internal Standard for Quantitative Analysis: Serves as a critical reference standard in LC-MS and GC-MS for the accurate quantification of fumaric acid and related metabolites in complex biological matrices.
• Metabolic Research: Used in tracer studies to investigate the citric acid cycle (Krebs cycle) and other metabolic pathways, enabling detailed understanding of biochemical processes.
• Pharmaceutical Development: Employed in pharmacokinetic and drug metabolism studies (DMPK) to track the absorption, distribution, metabolism, and excretion of new drug candidates.
• Isotope Dilution Mass Spectrometry (IDMS): Provides high-accuracy measurement capabilities in clinical diagnostics and environmental analysis where precision is paramount.
• Chemical Synthesis Research: Acts as a labeled starting material or intermediate for synthesizing more complex deuterated compounds for research purposes.
• Quality Control in Manufacturing: Used in analytical laboratories to ensure the accuracy and reliability of testing methods for fumaric acid in food, feed, and industrial products.

Basic Information

Product Name	Fumaric Acid-D4
CAS No.	194160-45-7
Molecular Formula	C4D4O4
Molecular Weight	120.10 g/mol
Synonyms	(2E)-But-2-enedioic-2,3-d2 Acid; (E)-2-Butenedioic-2,3-d2 Acid; Deuterated Fumaric Acid; Fumaric Acid-d4; Allomaleic Acid-d4; Boletic Acid-d4; trans-1,2-Ethylenedicarboxylic Acid-d4; Lichenic Acid-d4
EINECS	Contact for details

Quality Control

Our Fumaric Acid-D4 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, MS, and HPLC. A comprehensive Certificate of Analysis (COA) is provided, detailing isotopic enrichment (atom % D), chemical purity, and analytical results. We support compliance with relevant GMP and ISO guidelines for laboratory reagents.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The product is hygroscopic (moisture-sensitive); keep the container tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.