Description

5-Chlorosulfonyl-4-Methylisoquinoline is a high-value, multi-functional chemical intermediate characterized by its reactive chlorosulfonyl group. This compound is essential for the synthesis of complex molecules, enabling the introduction of sulfonamide or sulfonate functionalities. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the isoquinoline scaffold for biological activity.
• Material Science Research: Serves as a precursor for developing advanced polymers, ligands for catalysis, and specialty chemicals with unique electronic or photophysical properties.
• Chemical Biology & Proteomics: Utilized as a reactive handle for bioconjugation, labeling biomolecules, or creating activity-based probes for enzyme studies.
• Fine Chemical Production: Employed in custom synthesis and contract manufacturing for producing tailored sulfonamide derivatives and other specialty compounds.

Basic Information

Product Name	5-Chlorosulfonyl-4-Methylisoquinoline
CAS No.	194032-16-1
Molecular Formula	C₁₀H₈ClNO₂S
Molecular Weight	241.69 g/mol
Synonyms	4-Methylisoquinoline-5-sulfonyl chloride; 4-Methyl-5-isoquinolinesulfonyl chloride; 5-(Chlorosulfonyl)-4-methylisoquinoline; Isoquinoline-5-sulfonyl chloride, 4-methyl-; 194032-16-1; 4-Methylisoquinoline-5-sulphonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 5-Chlorosulfonyl-4-Methylisoquinoline is manufactured and tested under strict quality management protocols. We ensure high purity and consistency through advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.