Description

4-Bromo-1-(tert-Butyldimethylsilyl)Indole is a key protected indole derivative, specifically functionalized at the 1-position with a tert-butyldimethylsilyl (TBS) group and at the 4-position with a bromine atom. This compound is of significant value as a versatile and stable synthetic intermediate in advanced organic synthesis, particularly for the construction of complex heterocyclic systems. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the indole scaffold's bioactivity.
• Material Science: Acts as a precursor for organic electronic materials, including organic light-emitting diodes (OLEDs) and semiconductors.
• Cross-Coupling Reactions: The bromine atom at the 4-position makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Negishi couplings for further functionalization.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies by allowing selective modifications to the indole core.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development and the synthesis of complex natural product analogs.

Basic Information

Product Name	4-Bromo-1-(tert-Butyldimethylsilyl)Indole
CAS No.	193694-04-1
Molecular Formula	C14H20BrNSi
Molecular Weight	310.31 g/mol
Synonyms	1-[(1,1-Dimethylethyl)dimethylsilyl]-4-bromo-1H-indole; 4-Bromo-1-[(tert-butyldimethylsilyl)]-1H-indole; 4-Bromo-1-TBS-indole; 4-Bromoindole, 1-(tert-butyldimethylsilyl)-; 1H-Indole, 4-bromo-1-[(1,1-dimethylethyl)dimethylsilyl]-; TBS-4-Bromoindole; 4-Br-1-TBSI
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-(tert-Butyldimethylsilyl)Indole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry for comprehensive characterization. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.