Description

1H-Indene-2-Carboxylic Acid, 1-Amino-2,3-Dihydro-, Methyl Ester, Hydrochloride is a high-purity, functionalized indene derivative with significant synthetic utility. This compound serves as a versatile and valuable pharmaceutical intermediate and building block in advanced organic synthesis. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular drugs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its fused ring structure.
• Ligand and Catalyst Development: Serves as a starting material for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Acts as a monomer or functional additive in the development of advanced polymers and organic electronic materials.
• Chemical Biology Probes: Utilized in medicinal chemistry for the design and synthesis of molecular probes to study biological pathways.
• Custom Synthesis and Contract Manufacturing: A critical building block for custom synthesis projects and scale-up processes under cGMP conditions.

Basic Information

Product Name	1H-Indene-2-Carboxylic Acid, 1-Amino-2,3-Dihydro-, Methyl Ester, Hydrochloride
CAS No.	193634-34-3
Molecular Formula	C11H14ClNO2
Molecular Weight	227.69 g/mol
Synonyms	1-Amino-2,3-dihydro-1H-indene-2-carboxylic acid methyl ester hydrochloride; Methyl 1-amino-2,3-dihydro-1H-indene-2-carboxylate hydrochloride; (1R,2S)-rel-1-Amino-2,3-dihydro-1H-indene-2-carboxylic Acid Methyl Ester Hydrochloride; 1-Aminoindane-2-carboxylic acid methyl ester HCl; 2-Carbomethoxy-1-aminoindane hydrochloride; Aminoindane-2-carboxylate methyl ester hydrochloride; 1-Amino-2,3-dihydro-1H-indene-2-carboxylic acid methyl ester HCl salt
EINECS	Contact for details

Quality Control

Every batch of 1H-Indene-2-Carboxylic Acid, 1-Amino-2,3-Dihydro-, Methyl Ester, Hydrochloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for pharmaceutical and advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, chiral purity (where applicable), and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee (if applicable)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.