Description

1-Boc-3-Bromo-5-Azaindole is a high-value, protected heterocyclic building block of significant importance in modern organic synthesis. This compound serves as a versatile intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process R&D scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel active compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of kinase inhibitors and other small molecule drug candidates targeting various therapeutic areas.
• Medicinal Chemistry: Used for structure-activity relationship (SAR) studies and lead optimization campaigns due to its reactive bromine and protected nitrogen functionalities.
• Agrochemical Synthesis: Building block for developing novel active ingredients with potential herbicidal or insecticidal properties.
• Chemical Biology: Employed in the creation of molecular probes and tool compounds for studying biological pathways.
• Material Science: Potential monomer or precursor for specialty polymers and advanced organic electronic materials.
• Cross-Coupling Reactions: The 3-bromo substituent makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions.

Basic Information

Product Name	1-Boc-3-Bromo-5-Azaindole
CAS No.	192189-16-5
Molecular Formula	C₁₂H₁₃BrN₂O₂
Molecular Weight	297.15 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-3-bromo-1H-pyrrolo[2,3-b]pyridine; 3-Bromo-1-[(2-methylpropan-2-yl)oxycarbonyl]-1H-pyrrolo[2,3-b]pyridine; 3-Bromo-1-Boc-7-azaindole; 3-Bromo-1-Boc-5-azaindole; tert-Butyl 3-bromo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate; 1-Boc-3-bromo-7-azaindole; 3-Bromo-1-(tert-butoxycarbonyl)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 1-Boc-3-Bromo-5-Azaindole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) detailing purity, impurities, and full characterization data are provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.