Description

1-Boc-3-Bromo-1H-Pyrrolo[3,2-B]Pyridine is a high-value, multi-functional heterocyclic building block used in advanced organic synthesis. Its core value lies in providing a protected, reactive site for constructing complex molecular architectures, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working in drug discovery, agrochemicals, and materials science.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, leveraging its heterocyclic core for bioactivity.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for metal-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to introduce complex substituents.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Library Synthesis for Drug Discovery: Enables the rapid generation of diverse compound libraries for high-throughput screening (HTS) campaigns.

Basic Information

Product Name	1-Boc-3-Bromo-1H-Pyrrolo[3,2-B]Pyridine
CAS No.	192189-15-4
Molecular Formula	C₁₂H₁₃BrN₂O₂
Molecular Weight	297.15 g/mol
Synonyms	1-Boc-3-bromo-7-azaindole; tert-Butyl 3-bromo-1H-pyrrolo[3,2-b]pyridine-1-carboxylate; 3-Bromo-1-[(tert-butoxy)carbonyl]-1H-pyrrolo[3,2-b]pyridine; 3-Bromo-1H-pyrrolo[3,2-b]pyridine-1-carboxylic acid tert-butyl ester; 1-Boc-3-bromo-1H-pyrrolo[3,2-b]pyridine; 3-Bromo-1-Boc-7-azaindole; 1-(tert-Butoxycarbonyl)-3-bromo-1H-pyrrolo[3,2-b]pyridine
EINECS	Contact for details

Quality Control

Our 1-Boc-3-Bromo-1H-Pyrrolo[3,2-B]Pyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. All batches are analyzed using advanced analytical techniques, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.