Description

4-Chloroaniline-2,3,5,6-D4 is a deuterium-labeled analog of 4-chloroaniline, a key intermediate in organic synthesis and analytical chemistry. This stable isotopically labeled compound is essential for creating internal standards in mass spectrometry, enabling precise quantification and metabolic pathway tracing in complex matrices. It is primarily utilized by research institutions, pharmaceutical developers, and analytical laboratories engaged in advanced chemical synthesis, environmental analysis, and drug metabolism studies.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a critical reference standard in LC-MS and GC-MS analysis for the accurate quantification of 4-chloroaniline and related compounds in biological and environmental samples.
• Metabolic Pathway Tracing: Used in pharmaceutical R&D to study the absorption, distribution, metabolism, and excretion (ADME) of chloroaniline-containing drug candidates.
• Deuterated Intermediate Synthesis: Acts as a building block for the synthesis of more complex deuterium-labeled molecules for research and diagnostic applications.
• Environmental Analysis: Employed in method development and validation for detecting trace levels of chloroaniline pollutants in water, soil, and industrial waste.
• Chemical Mechanism Studies: Utilized in kinetic and mechanistic studies where isotopic labeling is required to track reaction pathways.
• Quality Control Reference: Provides a high-purity standard for calibrating analytical instruments and verifying the purity of commercial 4-chloroaniline batches.

Basic Information

Product Name	4-Chloroaniline-2,3,5,6-D4
CAS No.	191656-33-4
Molecular Formula	C6D4ClN
Molecular Weight	131.59 g/mol (approx.)
Synonyms	4-Chloroaniline-d4; p-Chloroaniline-d4; 1-Amino-4-chlorobenzene-2,3,5,6-d4; 4-Chloro-1-aminobenzene-d4; Deuteronated 4-Chloroaniline; [2,3,5,6-2H4]-4-Chloroaniline; p-Chlorophenylamine-d4; 4-CA-d4
EINECS	Contact for details

Quality Control

Our 4-Chloroaniline-2,3,5,6-D4 is manufactured under strict quality management systems to ensure high chemical and isotopic purity. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm deuterium incorporation and chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and impurity profile is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.