Description

Methyl 5-(Difluoromethyl)Thiophene-2-Carboxylate is a high-value, fluorinated heterocyclic building block essential for advanced organic synthesis. This compound is prized for its role in introducing the difluoromethylthiophene moiety, a key structural feature that can modulate the physicochemical and metabolic properties of target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a precursor for functionalized thiophene monomers in the development of organic electronic materials, such as semiconductors for OLEDs or organic photovoltaics.
• Chemical Biology & Proteomics: Employed as a building block for designing chemical probes and affinity tags that leverage the unique properties of the fluorine atoms.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	Methyl 5-(Difluoromethyl)Thiophene-2-Carboxylate
CAS No.	189331-34-8
Molecular Formula	C7H6F2O2S
Molecular Weight	192.18 g/mol
Synonyms	Methyl 5-(difluoromethyl)thiophene-2-carboxylate; 5-(Difluoromethyl)thiophene-2-carboxylic acid methyl ester; 2-Thiophenecarboxylic acid, 5-(difluoromethyl)-, methyl ester; Methyl 5-difluoromethylthiophene-2-carboxylate; 189331-34-8; Methyl 5-(Difluoromethyl)-2-thiophenecarboxylate
EINECS	Contact for details

Quality Control

Every batch of Methyl 5-(Difluoromethyl)Thiophene-2-Carboxylate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and consistency suitable for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.