Description

3-(Difluoromethyl)Thiophene-2-Carboxylic Acid is a high-purity, versatile heterocyclic building block characterized by its reactive carboxylic acid group and difluoromethyl-substituted thiophene core. This compound is valued for its role in introducing the metabolically stable difluoromethyl group into target molecules, which is a critical strategy in modern medicinal chemistry and agrochemical design. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group enhances biological activity and stability.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers and functional materials with unique electronic properties.
• Chemical Biology & Proteomics: Employed as a building block for creating chemical probes and activity-based protein profiling (ABPP) reagents.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis services catering to R&D and pilot-scale production needs.

Basic Information

Product Name	3-(Difluoromethyl)Thiophene-2-Carboxylic Acid
CAS No.	189330-25-4
Molecular Formula	C6H4F2O2S
Molecular Weight	178.16 g/mol
Synonyms	2-Thiophenecarboxylic acid, 3-(difluoromethyl)-; 3-(Difluoromethyl)-2-thiophenecarboxylic acid; 3-Difluoromethylthiophene-2-carboxylic acid; 3-(Difluoromethyl)thiophene-2-carboxylic acid; 189330-25-4; 3-(Difluoromethyl)-2-thiophenecarboxylic acid; 3-(Difluoromethyl)thiophene-2-carboxylic acid; 3-Difluoromethyl-2-thiophenecarboxylic acid
EINECS	Contact for details

Quality Control

Our production of 3-(Difluoromethyl)Thiophene-2-Carboxylic Acid adheres to stringent quality management protocols. Every batch is analyzed using advanced techniques like HPLC, GC, and NMR to ensure identity, purity, and consistency meet exacting customer requirements. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment, supporting regulatory documentation for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.