Description

Ethyl 2-(Thiophene-2-Carboxamido)-5,6-Dihydro-4H-Cyclopenta[B]Thiophene-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate with a complex fused-ring thiophene structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated heterocyclic scaffolds. It is primarily sought by research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in the development of new chemical entities for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, or oncology.
• Organic Synthesis Research: Used in academic and industrial R&D for constructing complex polycyclic thiophene derivatives and studying structure-activity relationships (SAR).
• Agrochemical Development: Serves as a precursor in the research and development of new generation pesticides and herbicides that utilize thiophene-based chemistry.
• Material Science: Investigated as a monomer or precursor for the development of organic semiconductors and conductive polymers due to its electron-rich thiophene units.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects under cGMP conditions.

Basic Information

Product Name	Ethyl 2-(Thiophene-2-Carboxamido)-5,6-Dihydro-4H-Cyclopenta[B]Thiophene-3-Carboxylate
CAS No.	189067-62-7
Molecular Formula	C15H15NO3S2
Molecular Weight	321.41 g/mol
Synonyms	Ethyl 2-[(thiophene-2-carbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate; 2-(Thiophene-2-carboxamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid ethyl ester; 189067-62-7; Cyclopenta[b]thiophene-3-carboxylic acid, 2-[(2-thienylcarbonyl)amino]-4,5,6,7-tetrahydro-, ethyl ester; Ethyl 2-(2-thiophenecarboxamido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 2-(Thiophene-2-Carboxamido)-5,6-Dihydro-4H-Cyclopenta[B]Thiophene-3-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support development and commercial projects with material suitable for research use and can supply grades aligned with ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.