Description

(S)-α-(2-Amino-5-Chlorophenyl)-2,3-Dimethoxybenzenemethanol is a chiral benzhydrol derivative of significant interest in advanced organic synthesis. This compound matters as a key chiral intermediate or building block for the development of active pharmaceutical ingredients (APIs) and other fine chemicals, where its specific stereochemistry is crucial for biological activity. Pharmaceutical research and development laboratories, as well as fine chemical manufacturers, need this high-purity intermediate to create novel therapeutic agents, particularly in neurological and cardiovascular drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular drugs.
• Asymmetric Synthesis: Used as a chiral auxiliary or precursor in stereoselective chemical reactions to introduce desired chirality into complex molecular frameworks.
• Medicinal Chemistry Research: Employed in drug discovery and lead optimization programs to explore structure-activity relationships (SAR) and develop new therapeutic candidates.
• Fine Chemical Production: Acts as a specialized intermediate in the multi-step synthesis of high-value agrochemicals, dyes, and advanced materials.
• Reference Standard: Utilized as an analytical standard for quality control and method development in pharmaceutical analysis and regulatory submissions.
• Catalyst Ligand Precursor: Can be modified to form chiral ligands for metal-catalyzed asymmetric transformations in industrial chemistry.

Basic Information

Product Name	(S)-α-(2-Amino-5-Chlorophenyl)-2,3-Dimethoxybenzenemethanol
CAS No.	189059-58-3
Molecular Formula	C15H16ClNO3
Molecular Weight	293.75 g/mol
Synonyms	(S)-α-(2-Amino-5-chlorophenyl)-2,3-dimethoxybenzenemethanol; (S)-2,3-Dimethoxy-α-(2-amino-5-chlorophenyl)benzyl Alcohol; (S)-Benzenemethanol, α-(2-amino-5-chlorophenyl)-2,3-dimethoxy-; (S)-2,3-Dimethoxy-α-(2-amino-5-chlorophenyl)phenylmethanol; (S)-2,3-Dimethoxy-α-(2-amino-5-chlorophenyl)benzyl Alcohol; (S)-2,3-Dimethoxy-α-(2-amino-5-chlorophenyl)phenylcarbinol; (S)-2,3-Dimethoxy-α-(2-amino-5-chlorophenyl)benzyl Alcohol; (S)-α-(2-Amino-5-chlorophenyl)-2,3-dimethoxybenzyl Alcohol
EINECS	Contact for details

Quality Control

Our (S)-α-(2-Amino-5-Chlorophenyl)-2,3-Dimethoxybenzenemethanol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific customer or regulatory requirements (e.g., ICH guidelines).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended for optimal stability. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.