Description

1-((2-(Trimethylsilyl)Ethoxy)Methyl)Pyrazole-5-Boronic is a specialized organoboron reagent featuring a protected pyrazole core, designed for advanced synthetic applications. This compound matters because it serves as a critical building block in modern pharmaceutical and agrochemical research, enabling the formation of carbon-carbon and carbon-heteroatom bonds through efficient cross-coupling reactions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex heterocyclic molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing pyrazole or related heterocyclic scaffolds.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic acid partner for palladium-catalyzed coupling with aryl/heteroaryl halides, a cornerstone reaction in medicinal chemistry.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that incorporate pyrazole motifs for enhanced biological activity.
• Material Science Research: Employed in the development of organic electronic materials, ligands for catalysis, and metal-organic frameworks (MOFs).
• Chemical Biology & Probe Development: Utilized to create molecular probes and labeled compounds for studying biological pathways and target engagement.
• Process Chemistry & Scale-up: Provides a reliable and scalable synthon for the pilot and commercial-scale manufacturing of target molecules.

Basic Information

Product Name	1-((2-(Trimethylsilyl)Ethoxy)Methyl)Pyrazole-5-Boronic
CAS No.	188978-71-4
Molecular Formula	C10H21BN2O2Si
Molecular Weight	240.19 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole; 1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrazole-5-boronic acid, pinacol ester; 1-((2-(Trimethylsilyl)ethoxy)methyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1H-Pyrazole-5-boronic acid, 1-((2-(trimethylsilyl)ethoxy)methyl)-, pinacol ester; 1-SEM-Pyrazole-5-boronic acid pinacol ester; Pyrazole-5-boronic acid SEM-protected pinacol ester
EINECS	Contact for details

Quality Control

Our 1-((2-(Trimethylsilyl)Ethoxy)Methyl)Pyrazole-5-Boronic is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and GC, to ensure high purity and consistency suitable for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.