Description

B-[1-[[2-(Trimethylsilyl)Ethoxy]Methyl]-1H-Imidazol-5-Yl]Boronic Acid is a sophisticated organoboron building block featuring a protected imidazole core. This compound is of significant value in modern synthetic chemistry, particularly for its role in facilitating key carbon-carbon and carbon-heteroatom bond-forming reactions. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing imidazole-based heterocycles.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic acid coupling partner for the palladium-catalyzed synthesis of biaryl and heteroaryl compounds.
• Medicinal Chemistry Research: Used in high-throughput screening and lead optimization for discovering novel drug candidates.
• Agrochemical Synthesis: Employed in the development of new fungicides, herbicides, and insecticides that require specific heterocyclic frameworks.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Useful for creating tagged molecules to study biological pathways and protein interactions.

Basic Information

Product Name	B-[1-[[2-(Trimethylsilyl)Ethoxy]Methyl]-1H-Imidazol-5-Yl]Boronic Acid
CAS No.	188978-35-0
Molecular Formula	C10H21BN2O3Si
Molecular Weight	256.18 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole; 1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-imidazole-5-boronic acid, pinacol ester; 1-((2-(Trimethylsilyl)ethoxy)methyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-imidazole; 5-Borono-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole; B-(1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)boronic acid; SEM-Protected Imidazole-5-boronic Acid Pinacol Ester; CAS 188978-35-0
EINECS	Contact for details

Quality Control

Our B-[1-[[2-(Trimethylsilyl)Ethoxy]Methyl]-1H-Imidazol-5-Yl]Boronic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.