Description

Ethyl 3-(5-Chlorothiophen-2-Yl)-3-Oxopropanoate is a high-purity, versatile β-keto ester derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its value lies in its reactive carbonyl and ester functional groups, which enable efficient construction of complex heterocyclic and pharmaceutical scaffolds. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those containing thiophene or chlorinated heterocyclic cores.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides.
• Material Science Research: Precursor for the development of organic electronic materials, dyes, and functional polymers.
• Chemical Research & Development: A versatile reagent for studying Claisen condensation, Michael addition, and other key organic transformations.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and APIs on a commercial scale.

Basic Information

Product Name	Ethyl 3-(5-Chlorothiophen-2-Yl)-3-Oxopropanoate
CAS No.	188937-11-3
Molecular Formula	C9H9ClO3S
Molecular Weight	232.68 g/mol
Synonyms	Ethyl 3-(5-chloro-2-thienyl)-3-oxopropanoate; Ethyl (5-chloro-2-thienoyl)acetate; 3-Oxobutanoic acid, 3-(5-chloro-2-thienyl)-, ethyl ester; 5-Chloro-2-thienyl 3-oxobutanoate ethyl ester; Acetic acid, [(5-chloro-2-thienyl)carbonyl]-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 3-(5-Chlorothiophen-2-Yl)-3-Oxopropanoate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with REACH and other global regulatory frameworks, and specifications can be tailored to meet specific GMP or research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.