Description

(S)-2-Mercaptomethyl-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity chiral building block of significant importance in modern synthetic chemistry. Its value lies in its role as a key intermediate for constructing complex molecules with defined stereochemistry, particularly in the pharmaceutical sector. This compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), especially those targeting neurological and cardiovascular diseases.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, particularly in protease inhibitor research.
• Asymmetric Synthesis: Used as a ligand precursor or auxiliary in catalytic asymmetric reactions to induce high enantioselectivity.
• Peptidomimetics Development: Serves as a constrained proline analogue for creating stable, bioactive peptide mimics.
• Chemical Biology Probes: Utilized in the development of activity-based probes for studying enzyme function and mechanism.
• Agrochemical Research: Employed in the discovery of new chiral active ingredients with improved efficacy and environmental profiles.
• Material Science: Investigated as a monomer or cross-linker for advanced polymers with specific functional properties.

Basic Information

Product Name	(S)-2-Mercaptomethyl-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	188625-66-3
Molecular Formula	C10H19NO2S
Molecular Weight	217.33 g/mol
Synonyms	(S)-1-(tert-Butoxycarbonyl)-2-(mercaptomethyl)pyrrolidine; (S)-N-Boc-2-(mercaptomethyl)pyrrolidine; (S)-2-Mercaptomethyl-1-Boc-pyrrolidine; tert-Butyl (S)-2-(mercaptomethyl)pyrrolidine-1-carboxylate; (S)-2-Mercaptomethylpyrrolidine-1-carboxylic Acid tert-Butyl Ester; (S)-Boc-2-(mercaptomethyl)pyrrolidine; (S)-1-Boc-2-mercaptomethylpyrrolidine; (2S)-2-(Mercaptomethyl)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-2-Mercaptomethyl-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and GC/HPLC for chemical purity and impurity profiling. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a dry, cool, and well-ventilated area. Due to its sensitivity to oxidation, the container should only be opened in an inert environment and material should be used promptly after opening.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.