Description

tert-Butyl 7-Hydroxy-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is a high-purity, protected heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because it serves as a critical intermediate for constructing complex molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and other specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, cardiovascular diseases, and other therapeutic areas.
• Agrochemical Research: Used as a building block for developing new active ingredients in crop protection and pest management products.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex organic molecules for material science, dyes, and other specialty applications.
• Academic & Contract Research: Serves as a valuable reagent in university laboratories and CROs (Contract Research Organizations) for methodological studies and novel compound library generation.
• Process Chemistry Development: Utilized in scaling up synthetic routes from laboratory to pilot plant and commercial production scales.

Basic Information

Product Name	tert-Butyl 7-Hydroxy-3,4-Dihydroisoquinoline-2(1H)-Carboxylate
CAS No.	188576-49-0
Molecular Formula	C₁₄H₁₉NO₃
Molecular Weight	249.31 g/mol
Synonyms	7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-7-hydroxy-, 1,1-dimethylethyl ester; 7-Hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester; Boc-7-OH-THIQ; tert-Butyl 7-hydroxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; 188576-49-0; 7-Hydroxy-N-Boc-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-Hydroxy-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.