Description

(R)-A-Hydroxy-3-Thiopheneacetonitrile is a high-purity chiral building block and synthetic intermediate of significant importance in advanced organic synthesis. Its value lies in its unique stereochemistry and functional groups, which make it a critical precursor for constructing complex, biologically active molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the production of advanced, stereoselective pesticides and herbicides where specific chirality enhances efficacy and reduces environmental impact.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of novel organic electronic materials and functionalized polymers containing thiophene units.
• Academic & Process Chemistry: A valuable reagent for methodological studies in organic chemistry, including new asymmetric transformation routes.

Basic Information

Product Name	(R)-A-Hydroxy-3-Thiopheneacetonitrile
CAS No.	188481-44-9
Molecular Formula	C7H7NOS
Molecular Weight	153.20 g/mol
Synonyms	(R)-2-Hydroxy-2-(thiophen-3-yl)acetonitrile; (R)-α-Hydroxy-3-thiopheneacetonitrile; (R)-Hydroxy(thiophen-3-yl)acetonitrile; 3-Thiopheneacetonitrile, α-hydroxy-, (R)-; (R)-3-Thienylglycolonitrile; (R)-TGA; (R)-TAN
EINECS	Contact for details

Quality Control

Our (R)-A-Hydroxy-3-Thiopheneacetonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) specifying identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.