Description

[7-Cd3]-1,3,7-Trimethyluric Acid is a stable isotope-labeled analog of 1,3,7-Trimethyluric acid, a key metabolite of caffeine. This deuterated compound is essential for use as an internal standard in quantitative analytical methods, ensuring high accuracy and precision in measurement. It is primarily required by analytical laboratories, pharmaceutical R&D departments, and contract research organizations (CROs) engaged in pharmacokinetic studies, drug metabolism research, and clinical diagnostics.

Application

• Primary use as an Internal Standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the quantification of caffeine and its metabolites.
• Critical component in Deuterium-Labeled Analytical Kits for clinical and forensic toxicology testing.
• Essential reference material for Pharmacokinetic and Drug Metabolism Studies in pharmaceutical development.
• Used in Stable Isotope Dilution Assays to achieve superior accuracy in complex biological matrices like plasma, serum, and urine.
• Research tool in Nutritional Science and Sports Medicine for studying caffeine metabolism and clearance rates.
• Calibration standard for ensuring regulatory compliance in Good Laboratory Practice (GLP) and ISO 17025 accredited laboratories.

Basic Information

Product Name	[7-Cd3]-1,3,7-Trimethyluric Acid
CAS No.	188297-95-2
Molecular Formula	C8H8D3N4O3
Molecular Weight	210.20 g/mol
Synonyms	1,3,7-Trimethyluric Acid-d3; 1,3,7-Trimethyl-2,6,8(1H,3H,9H)-purinetrione-7-d3; 7-Deuterio-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6,8-trione; Caffeine Metabolite-d3; TMU-d3; Deuterated Trimethyluric Acid; 7-(2H3)-1,3,7-Trimethyluric Acid
EINECS	Contact for details

Quality Control

Our [7-Cd3]-1,3,7-Trimethyluric Acid is manufactured under controlled conditions to ensure exceptional isotopic and chemical purity, critical for its role as an analytical standard. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (Atom % D), chemical purity (by HPLC), and identity confirmation (by NMR and MS). We adhere to stringent quality protocols suitable for GMP and GLP environments, ensuring reliability and traceability for your most demanding applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.