Description

L-Isoleucine, n-(3,4-Dihydro-3,3-Dimethyl-1-Isoquinolinyl)- is a specialized, non-proteinogenic amino acid derivative that combines the structural features of L-isoleucine with a tetrahydroisoquinoline moiety. This unique molecular architecture makes it a valuable advanced pharmaceutical intermediate and a versatile building block for medicinal chemistry research. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis sectors for the development of novel bioactive compounds and potential drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Serves as a critical building block for constructing complex molecular libraries and exploring structure-activity relationships (SAR).
• Peptidomimetic Design: Used in the synthesis of peptide analogs and mimetics to enhance metabolic stability and bioavailability.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies and biochemical assays.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective synthesis routes.
• Fine Chemical Production: A precursor for the manufacture of specialty chemicals and advanced materials.

Basic Information

Product Name	L-Isoleucine, n-(3,4-Dihydro-3,3-Dimethyl-1-Isoquinolinyl)-
CAS No.	187884-89-5
Molecular Formula	C₁₆H₂₂N₂O₂
Molecular Weight	274.36 g/mol
Synonyms	N-(3,4-Dihydro-3,3-dimethyl-1(2H)-isoquinolinyl)-L-isoleucine; (2S,3S)-2-Amino-3-methyl-N-(3,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-1-yl)pentanamide; L-Isoleucine, N-(3,4-dihydro-3,3-dimethyl-1-isoquinolinyl)-; Tetrahydroisoquinoline-L-isoleucine derivative; 1-(L-Isoleucylamino)-3,3-dimethyl-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our production of L-Isoleucine, n-(3,4-Dihydro-3,3-Dimethyl-1-Isoquinolinyl)- adheres to stringent quality protocols suitable for research and pharmaceutical intermediate applications. Each batch is characterized and tested to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specific chromatographic and spectroscopic data are provided with every shipment. We support compliance with cGMP and ISO 9001 standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.