Description

(3S)-3-(5-Chloro-2-Methoxy-Phenyl)-3-Fluoro-6-(Trifluoromethyl)-1H-Ind Ol-2-One is a high-purity, non-racemic chiral indole derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate or a potential pharmacophore for creating novel therapeutic agents. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries. The specific stereochemistry and functional groups make it a valuable building block for targeting complex biological pathways.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and high-throughput screening libraries to identify new drug candidates.
• Process Chemistry & Scale-Up: Serves as a critical intermediate in the development and optimization of scalable synthetic routes for potential drug substances.
• Biochemical Tool Compound: May be employed in biochemical assays to study enzyme inhibition or receptor modulation due to its specific fluorinated and chlorinated structure.
• Asymmetric Synthesis: Utilized in chiral synthesis to impart specific stereochemistry into more complex molecular architectures.

Basic Information

Item	Detail
Product Name	(3S)-3-(5-Chloro-2-Methoxy-Phenyl)-3-Fluoro-6-(Trifluoromethyl)-1H-Ind Ol-2-One
CAS No.	187523-35-9
Molecular Formula	C₁₇H₁₀ClF₄NO₂
Molecular Weight	371.71 g/mol
Synonyms	(3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)-1H-indol-2(3H)-one; (3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)indolin-2-one; (S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)indolin-2-one; 187523-35-9; 3-(5-Chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)-1H-indol-2-one (S-enantiomer); Chiral Fluorinated Indolinone Derivative
EINECS	Contact for details

Quality Control

Our (3S)-3-(5-Chloro-2-Methoxy-Phenyl)-3-Fluoro-6-(Trifluoromethyl)-1H-Ind Ol-2-One is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, NMR, and LC-MS for structural confirmation and impurity profiling. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or development specifications. Our commitment is to deliver high-purity, consistent material to support critical pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity. Keep the container sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.