Description

5-Aminolevulinic-2,2-D2 Acid Hcl is a deuterium-labeled derivative of 5-aminolevulinic acid hydrochloride, a key biochemical precursor in the heme biosynthesis pathway. This stable isotope-labeled compound is essential for advanced research and analytical applications where precise metabolic tracing is required. It is primarily utilized by pharmaceutical R&D teams, analytical laboratories, and academic institutions engaged in metabolic studies, pharmacokinetics, and the development of diagnostic agents.

Application

• Metabolic Pathway Tracing: Used as an internal standard in mass spectrometry for quantitative analysis of 5-ALA and its metabolites in biological samples.
• Pharmacokinetic Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) for 5-ALA-based therapeutics.
• Biochemical Research: Serves as a critical tool in studying the heme biosynthesis pathway and related disorders like porphyrias.
• Development of Photodynamic Therapy (PDT): Used in research for optimizing 5-ALA-induced protoporphyrin IX accumulation in cancer cells.
• Analytical Reference Standard: Provides a high-purity, isotopically labeled reference material for ensuring accuracy in HPLC-MS and LC-MS/MS methods.
• Diagnostic Agent Research: Supports the development of enhanced diagnostic protocols for tumors and other conditions.

Basic Information

Product Name	5-Aminolevulinic-2,2-D2 Acid Hcl
CAS No.	187237-35-0
Molecular Formula	C5H7D2ClN2O3
Molecular Weight	182.62 g/mol
Synonyms	5-ALA-2,2-D2 Hydrochloride; 5-Amino-4-oxopentanoic-2,2-D2 Acid Hydrochloride; δ-Aminolevulinic-2,2-D2 Acid HCl; 5-Amino-4-oxopentanoic Acid-2,2-D2 Hydrochloride; Deuterated 5-Aminolevulinic Acid HCl; 2,2-Dideutero-5-aminolevulinic Acid Hydrochloride; 5-ALA-D2 HCl; ALA-D2 Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of our 5-Aminolevulinic-2,2-D2 Acid Hcl is manufactured and tested under strict quality management systems. We ensure high chemical purity, isotopic enrichment, and batch-to-batch consistency suitable for sensitive analytical and research applications. Comprehensive testing includes identity confirmation, assay, isotopic purity, and impurity profiling. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Isotopic Purity (D2)	≥98 atom % D
Chemical Purity (HPLC)	≥95.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.