Description

(R)-2-Tetrahydroisoquinoline Acetic Acid Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate. This compound is critical for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily needed by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in asymmetric synthesis and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug molecules, particularly those targeting neurological and cardiovascular systems.
• Asymmetric Synthesis: Used as a precursor or catalyst ligand in stereoselective reactions to construct molecules with defined three-dimensional configurations.
• Research & Development: Serves as a standard or starting material in medicinal chemistry for exploring new chemical entities and structure-activity relationships.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, agrochemicals, and advanced materials requiring high enantiomeric purity.
• Academic Studies: Utilized in university and institutional research for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	(R)-2-Tetrahydroisoquinoline Acetic Acid Hydrochloride
CAS No.	187218-03-7
Molecular Formula	C11H14ClNO2 • HCl
Molecular Weight	260.14 g/mol
Synonyms	(R)-1,2,3,4-Tetrahydro-2-isoquinolineacetic acid hydrochloride; (R)-Tic-OH•HCl; (R)-2-Carboxymethyl-1,2,3,4-tetrahydroisoquinoline hydrochloride; (R)-2-(1,2,3,4-Tetrahydro-2-isoquinolinyl)acetic acid hydrochloride; (R)-2-TIQAA•HCl; (2R)-1,2,3,4-Tetrahydroisoquinoline-2-acetic acid hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-2-Tetrahydroisoquinoline Acetic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.